/* Japan Pharma Regulatory Brief — shared design system (home + every data page) */
:root{
  --paper:#f3efe6;--paper-2:#ebe5d8;--card:#fbf9f4;--ink:#141412;--ink-2:#3b3a36;--muted:#7a756b;
  --line:rgba(20,20,18,.13);--line-2:rgba(20,20,18,.07);--shu:#d9381e;--shu-dk:#b02a14;--ai:#1f2b49;
  --serif:"Instrument Serif","Iowan Old Style","Times New Roman",serif;
  --sans:Inter,-apple-system,BlinkMacSystemFont,"Segoe UI",Roboto,Arial,sans-serif;
  --mono:"JetBrains Mono",ui-monospace,SFMono-Regular,Menlo,Consolas,monospace;
  --jp:"Noto Serif JP","Hiragino Mincho ProN","Yu Mincho",serif;
  --gut:clamp(18px,3.2vw,48px);--max:1320px;
  /* legacy names used by page-specific CSS */
  --bg:var(--paper);--soft:var(--card);--accent:var(--shu);--accent-dark:var(--shu-dk);--red:var(--shu)
}
*{box-sizing:border-box}
html{-webkit-text-size-adjust:100%;scroll-behavior:smooth}
body{margin:0;background:var(--paper);color:var(--ink);font:400 16px/1.6 var(--sans);-webkit-font-smoothing:antialiased;text-rendering:optimizeLegibility}
body::before{content:"";position:fixed;inset:0;pointer-events:none;z-index:100;opacity:.35;mix-blend-mode:multiply;
  background-image:url("data:image/svg+xml,%3Csvg xmlns='http://www.w3.org/2000/svg' width='180' height='180'%3E%3Cfilter id='n'%3E%3CfeTurbulence type='fractalNoise' baseFrequency='.85' numOctaves='2' stitchTiles='stitch'/%3E%3CfeColorMatrix values='0 0 0 0 .5 0 0 0 0 .45 0 0 0 0 .38 0 0 0 .09 0'/%3E%3C/filter%3E%3Crect width='100%25' height='100%25' filter='url(%23n)'/%3E%3C/svg%3E")}
::selection{background:var(--shu);color:#fff}
a{color:var(--ink);text-decoration-color:rgba(217,56,30,.55);text-underline-offset:3px;text-decoration-thickness:1px;transition:color .2s,text-decoration-color .2s}
a:hover{color:var(--shu);text-decoration-color:var(--shu)}
img{max-width:100%;display:block}
.sr{position:absolute!important;width:1px;height:1px;overflow:hidden;clip:rect(0 0 0 0);white-space:nowrap}
:focus-visible{outline:2px solid var(--shu);outline-offset:3px}
.wrap{max-width:var(--max);margin:0 auto;padding:0 var(--gut)}
.wrap.narrow{max-width:980px}
.grid12{display:grid;grid-template-columns:repeat(12,1fr);gap:0 24px}
em{font-style:italic}

/* ---------- header ---------- */
header.top{position:sticky;top:0;z-index:50;background:rgba(243,239,230,.86);backdrop-filter:saturate(1.4) blur(14px);-webkit-backdrop-filter:saturate(1.4) blur(14px);border-bottom:1px solid var(--line)}
header.top .bar{display:flex;align-items:center;justify-content:space-between;gap:20px;min-height:64px}
.brand{display:inline-flex;align-items:center;gap:11px;text-decoration:none;color:var(--ink);white-space:nowrap}
.brand svg{flex:0 0 30px;width:30px;height:30px}
.brand .wm{font-family:var(--serif);font-size:22px;line-height:1;letter-spacing:-.01em}
.brand .wm i{color:var(--shu)}
.brand:hover{color:var(--ink)}
nav.primary{display:flex;align-items:center;gap:4px}
nav.primary>a,nav.primary summary{font:500 14px/1 var(--sans);color:var(--ink);text-decoration:none;padding:10px 12px;border-radius:999px;cursor:pointer;transition:background .2s}
nav.primary>a:hover,nav.primary summary:hover{background:rgba(20,20,18,.06);color:var(--ink)}
nav.primary>a.cur{background:rgba(20,20,18,.08)}
nav.primary a.subscribe{background:var(--ink);color:var(--paper);padding:11px 18px;margin-left:8px}
nav.primary a.subscribe:hover{background:var(--shu);color:#fff}
.menu{position:relative}
.menu summary{list-style:none;display:inline-flex;align-items:center;gap:7px}
.menu summary::-webkit-details-marker{display:none}
.menu summary::after{content:"";width:6px;height:6px;border-right:1.5px solid currentColor;border-bottom:1.5px solid currentColor;transform:translateY(-2px) rotate(45deg);transition:transform .25s}
.menu[open] summary::after{transform:translateY(1px) rotate(-135deg)}
.menu .panel{position:absolute;right:0;top:calc(100% + 12px);width:min(640px,92vw);background:var(--card);border:1px solid var(--line);border-radius:14px;box-shadow:0 30px 70px -30px rgba(30,20,0,.35);padding:14px;display:grid;grid-template-columns:1fr 1fr;gap:2px;animation:drop .22s ease-out}
.menu .panel a{display:block;padding:10px 12px;border-radius:8px;text-decoration:none;font-size:14.5px;color:var(--ink)}
.menu .panel a:hover,.menu .panel a.cur{background:var(--paper)}
.menu .panel a.cur{box-shadow:inset 2px 0 0 var(--shu)}
.menu .panel .hd{grid-column:1/-1;font:500 10.5px/1 var(--mono);letter-spacing:.1em;text-transform:uppercase;color:var(--muted);padding:6px 12px 10px}
@keyframes drop{from{opacity:0;transform:translateY(-6px)}}
@media (max-width:860px){
  nav.primary>a:not(.subscribe){display:none}
  .brand .wm{font-size:19px}
  .menu .panel{position:fixed;left:12px;right:12px;width:auto;top:70px;grid-template-columns:1fr;max-height:75vh;overflow:auto}
}
@media (max-width:420px){.brand .wm .x{display:none}nav.primary a.subscribe{padding:10px 14px}}

/* ---------- type & sections ---------- */
.eyebrow,.kicker{display:inline-flex;align-items:center;gap:10px;font:500 11.5px/1 var(--mono);letter-spacing:.1em;text-transform:uppercase;color:var(--ink-2);margin:0}
.eyebrow .dot{width:7px;height:7px;border-radius:50%;background:var(--shu)}
.kicker{color:var(--shu)}
.kicker.light{color:#e9735f}
.sec{padding:clamp(64px,9vw,130px) 0;border-top:1px solid var(--line)}
.sec-paper2{background:var(--paper-2)}
.sec-head{display:grid;gap:18px;margin:0 0 clamp(30px,4vw,56px)}
.sec-head.center{text-align:center;justify-items:center}
.sec-head h2,h2.h2{font-family:var(--serif);font-weight:400;font-size:clamp(38px,5vw,72px);line-height:.98;letter-spacing:-.02em;margin:0;max-width:18ch}
h2.h2{margin:18px 0 22px}
.sec-head h2 em,h2.h2 em{color:var(--shu)}
p.body{font-size:17px;line-height:1.6;color:var(--ink-2);max-width:60ch;margin:0 0 26px}
.reveal{opacity:0;transform:translateY(26px);transition:opacity 1s cubic-bezier(.2,.7,.2,1),transform 1s cubic-bezier(.2,.7,.2,1)}
.reveal.in{opacity:1;transform:none}
@media (prefers-reduced-motion:reduce){.reveal{opacity:1;transform:none;transition:none}html{scroll-behavior:auto}}

/* ---------- index of free data ---------- */
.idx{display:grid;grid-template-columns:repeat(3,1fr);border-top:1px solid var(--ink);border-left:1px solid var(--line)}
.idx a{position:relative;display:flex;flex-direction:column;gap:10px;min-height:210px;padding:24px 24px 26px;border-right:1px solid var(--line);border-bottom:1px solid var(--line);text-decoration:none;color:var(--ink);overflow:hidden;transition:background .35s,color .35s}
.idx a::after{content:"\2197";position:absolute;right:22px;top:20px;font-size:20px;transition:transform .35s}
.idx a:hover{background:var(--ink);color:var(--paper)}
.idx a:hover::after{transform:translate(4px,-4px);color:var(--shu)}
.idx a:hover p,.idx a:hover .no{color:#b9b3a7}
.idx .no{font:500 11px/1 var(--mono);color:var(--muted);letter-spacing:.06em}
.idx h3{font-family:var(--serif);font-weight:400;font-size:28px;line-height:1.05;margin:auto 0 0;letter-spacing:-.01em;max-width:14ch}
.idx p{margin:0;font-size:14px;line-height:1.5;color:var(--ink-2)}
.idx .lang{position:absolute;left:64px;top:24px;font:500 10.5px/1 var(--mono);color:var(--shu)}
@media (max-width:980px){.idx{grid-template-columns:1fr 1fr}}
@media (max-width:560px){.idx{grid-template-columns:1fr}.idx a{min-height:170px}}

/* ---------- data pages ---------- */
.hero{padding:clamp(44px,6vw,96px) 0 clamp(30px,4vw,56px);border-bottom:1px solid var(--ink);background:none}
.hero .eyebrow{color:var(--shu);margin:0 0 22px}
h1{font-family:var(--serif);font-weight:400;font-size:clamp(40px,6vw,92px);line-height:.95;letter-spacing:-.025em;margin:0 0 26px;max-width:20ch}
h2{font-family:var(--serif);font-weight:400;font-size:clamp(30px,3.4vw,46px);line-height:1.02;letter-spacing:-.015em;margin:0 0 18px}
h3{letter-spacing:-.01em}
.lead{font-size:clamp(17px,1.4vw,20px);line-height:1.55;color:var(--ink-2);max-width:62ch;margin:0 0 14px}
.updated{font:500 11.5px/1.6 var(--mono);letter-spacing:.06em;text-transform:uppercase;color:var(--muted);margin:18px 0 0}
section{padding:clamp(40px,5vw,72px) 0;border-top:1px solid var(--line)}
.hero+section{border-top:0}
.stats{display:grid;gap:0;grid-template-columns:repeat(auto-fit,minmax(200px,1fr));margin:30px 0 0;border-top:1px solid var(--line);border-left:1px solid var(--line)}
.stat{background:none;border:0;border-right:1px solid var(--line);border-bottom:1px solid var(--line);border-radius:0;padding:20px 20px 22px}
.stat b{display:block;font-family:var(--serif);font-weight:400;font-size:clamp(36px,3.6vw,52px);line-height:1;letter-spacing:-.02em;margin-bottom:8px}
.stat span{font-size:13.5px;color:var(--ink-2);line-height:1.45}
.filters{display:flex;flex-wrap:wrap;gap:10px;align-items:center;margin:0 0 16px}
.filters input,.filters select{padding:11px 14px;font:500 14.5px/1.2 var(--sans);color:var(--ink);background:var(--card);border:1px solid var(--line);border-radius:999px;outline:none;transition:border-color .2s,box-shadow .2s}
.filters input:focus,.filters select:focus{border-color:var(--ink);box-shadow:0 0 0 4px rgba(217,56,30,.12)}
.filters input[type=search]{flex:1 1 260px}
.filters label{font-size:14px;color:var(--ink-2)}
.count{font:500 11.5px/1 var(--mono);letter-spacing:.06em;text-transform:uppercase;color:var(--muted)}
.scroll{overflow:auto;max-height:78vh;border:1px solid var(--line);border-radius:12px;background:var(--card)}
table.data{width:100%;border-collapse:separate;border-spacing:0;font-size:14px;font-variant-numeric:tabular-nums}
table.data th,table.data td{padding:12px 14px;border-bottom:1px solid var(--line-2);text-align:left;vertical-align:top}
table.data th{background:var(--card);font:500 10.5px/1.3 var(--mono);letter-spacing:.08em;text-transform:uppercase;color:var(--muted);position:sticky;top:0;z-index:1;white-space:nowrap;border-bottom:1px solid var(--ink)}
table.data th[data-type]{cursor:pointer}
table.data th[data-type]:hover{color:var(--ink)}
table.data th[data-type]::after{content:" \2195";opacity:.35}
table.data th.asc::after{content:" \2191";opacity:1;color:var(--shu)}table.data th.desc::after{content:" \2193";opacity:1;color:var(--shu)}
table.data td.num{text-align:right;white-space:nowrap}
table.data td.date{white-space:nowrap;font-family:var(--mono);font-size:12.5px;color:var(--ink-2)}
table.data tbody tr{transition:background .15s}
table.data tbody tr:hover td{background:#f4f0e6}
table.data a{text-decoration-color:var(--line)}
.ja{font-size:12px;color:var(--muted)}
.jp{display:inline-block;font:600 9.5px/1.5 var(--mono);border:1px solid var(--line);color:var(--muted);border-radius:4px;padding:0 4px;vertical-align:1px}
.tag{display:inline-block;font:600 10px/1.6 var(--mono);letter-spacing:.04em;text-transform:uppercase;background:rgba(31,43,73,.07);color:var(--ai);padding:1px 8px;border-radius:99px;margin:2px 4px 0 0;white-space:nowrap}
.tag.samd{background:rgba(217,56,30,.09);color:var(--shu-dk)}
small{color:var(--muted)}
ul.months{columns:5 140px;padding:0;list-style:none;margin:0}
ul.months li{padding:7px 0;border-bottom:1px solid var(--line-2);break-inside:avoid;font-family:var(--mono);font-size:13px}
.signup-box,.signup:not(form){background:var(--ink);color:var(--paper);border-radius:16px;padding:clamp(26px,4vw,48px);margin:8px 0}
.signup:not(form) h2{color:var(--paper)}.signup:not(form) p{color:#bdb7ab;margin:0 0 18px}
.btn{display:inline-block;padding:14px 24px;font:600 15px/1 var(--sans);color:var(--ink);background:var(--paper);border-radius:999px;text-decoration:none;transition:background .25s,color .25s}
.btn:hover{background:var(--shu);color:#fff}
.attribution{border:0;border-left:2px solid var(--shu);background:var(--card);padding:16px 20px;border-radius:0 10px 10px 0;font-size:14px;color:var(--ink-2)}
.method p,.method li{font-size:15.5px;line-height:1.65;color:var(--ink-2);max-width:78ch}
tr.latest td{background:rgba(217,56,30,.045)}tr.latest:hover td{background:rgba(217,56,30,.08)}
tr:target td{background:#ffe9e3!important}
.new{display:inline-block;font:700 9.5px/1.6 var(--mono);letter-spacing:.06em;background:var(--shu);color:#fff;border-radius:4px;padding:0 5px;margin-left:5px;vertical-align:1px}
a.badge{display:inline-block;font:600 9.5px/1.7 var(--mono);letter-spacing:.04em;text-transform:uppercase;text-decoration:none;border-radius:99px;padding:0 8px;margin:3px 4px 0 0;background:rgba(91,42,158,.08);color:#5b2a9e;border:0;white-space:nowrap}
a.badge.sakigake{background:rgba(19,107,58,.09);color:#136b3a}a.badge.conditional{background:rgba(138,74,11,.09);color:#8a4a0b}
.related{background:var(--card);border:1px solid var(--line);border-radius:16px;padding:24px 26px}
.related h2{font-size:28px;margin:0 0 12px}.related ul{margin:0;padding:0;list-style:none;columns:2 280px}.related li{padding:8px 0;border-bottom:1px solid var(--line-2);break-inside:avoid}
table.mini{border-collapse:collapse;font-size:14px;margin:6px 0 0}table.mini th,table.mini td{border-bottom:1px solid var(--line);padding:8px 16px 8px 0;text-align:left}
table.mini th{font:500 10.5px/1.3 var(--mono);letter-spacing:.08em;text-transform:uppercase;color:var(--muted)}
table.mini .num{text-align:right}
.facts li{margin:6px 0}
.pager{display:flex;justify-content:space-between;gap:10px;font-size:15px;margin:18px 0 0}
.fixture{background:#fff3cd;border:2px solid #b8860b;color:#5c4300;padding:12px 16px;border-radius:8px;font-weight:700;margin:16px 0}
details>summary{cursor:pointer}

/* ---------- footer ---------- */
footer.site{background:var(--ink);color:#a8a296;padding:clamp(56px,7vw,96px) 0 40px;font-size:13.5px;line-height:1.6;border-top:0}
footer.site .big{font-family:var(--serif);color:var(--paper);font-size:clamp(40px,7vw,104px);line-height:.9;letter-spacing:-.02em;margin:0 0 clamp(36px,5vw,64px)}
footer.site .big i{color:var(--shu)}
footer.site .cols{display:grid;grid-template-columns:2fr 1fr 1fr;gap:clamp(24px,4vw,64px);padding-top:28px;border-top:1px solid rgba(243,239,230,.14)}
footer.site h4{font:500 10.5px/1 var(--mono);letter-spacing:.1em;text-transform:uppercase;color:#77726a;margin:0 0 14px}
footer.site a{color:var(--paper);text-decoration:none}
footer.site a:hover{color:var(--shu)}
footer.site ul{list-style:none;margin:0;padding:0}footer.site li{margin:0 0 8px}
footer.site .legal{margin-top:40px;padding-top:20px;border-top:1px solid rgba(243,239,230,.14);display:flex;justify-content:space-between;gap:20px;flex-wrap:wrap;font:500 11px/1.5 var(--mono);letter-spacing:.04em;color:#77726a}
footer.site p{margin:0 0 12px;max-width:70ch}
@media (max-width:760px){footer.site .cols{grid-template-columns:1fr}}
/* legacy footer on pages not yet using footer.site */
footer:not(.site){padding:28px 0 44px;font-size:13px;color:var(--muted);border-top:1px solid var(--line)}

/* ---------- data page hero mark ---------- */
.hero{position:relative;overflow:hidden}
.hero-kj{position:absolute;right:calc(var(--gut) + 14px);top:50%;transform:translateY(-46%);writing-mode:vertical-rl;font-family:var(--jp);font-weight:500;font-size:clamp(64px,7.5vw,120px);line-height:1;letter-spacing:.06em;white-space:nowrap;color:var(--shu);opacity:.92;pointer-events:none}
.hero-kj::after{content:"";position:absolute;inset:-16px -14px;border:1.5px solid rgba(217,56,30,.4);border-radius:3px}
.hero .wrap{position:relative}
@media (max-width:1100px){.hero-kj{opacity:.12;right:-10px}.hero-kj::after{display:none}}

/* ---------- small screens ---------- */
body{overflow-x:clip}
@media (max-width:560px){
  header.top .bar{gap:10px;min-height:58px}
  .brand{gap:8px}.brand svg{width:26px;height:26px;flex-basis:26px}
  .brand .wm{font-size:17px}.brand .wm .x{display:none}
  nav.primary summary{font-size:0;padding:10px}
  nav.primary summary::before{content:"Menu";font-size:14px}
  nav.primary a.subscribe{display:none}
  .menu .panel{top:64px}
  h1{font-size:clamp(38px,11vw,54px)}
  .updated{font-size:10.5px}
  .stat{padding:16px}
}